Metabolism of cisplatin to a nephrotoxin

Toxicology. 2009 Mar 29;257(3):174-5; author reply 176-7. doi: 10.1016/j.tox.2008.12.014. Epub 2008 Dec 24.
No abstract available

Publication types

  • Comment
  • Letter

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacokinetics*
  • Antineoplastic Agents / toxicity*
  • Biotransformation
  • Carbon-Sulfur Lyases / antagonists & inhibitors
  • Carbon-Sulfur Lyases / metabolism
  • Cells, Cultured
  • Cisplatin / pharmacokinetics*
  • Cisplatin / toxicity*
  • Enzyme Inhibitors / pharmacology
  • Humans
  • Isoxazoles / pharmacology
  • Kidney Diseases / chemically induced*
  • Lyases / metabolism
  • Mice
  • Rats
  • Transaminases / metabolism
  • gamma-Glutamyltransferase / antagonists & inhibitors

Substances

  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Isoxazoles
  • gamma-Glutamyltransferase
  • Transaminases
  • glutamine - phenylpyruvate transaminase
  • Lyases
  • Carbon-Sulfur Lyases
  • cysteine-S-conjugate beta-lyase
  • acivicin
  • Cisplatin