Mentoring is important for early-career HIV researchers; it is key for work satisfaction, productivity, workforce diversity, and retention of investigators in a variety of research settings. Establishment of multidisciplinary research projects often is accomplished through mentoring. The work of early-career HIV investigators frequently requires networks of collaborators, and networking is regularly facilitated by mentors. A structured mentoring program that avoids unnecessary conflicts or time burdens and connects early-career investigators with senior mentors from different disciplines may stimulate new networking possibilities and lead to effective collaborations among investigators with different skills and perspectives. Effective mentoring by focused mentors will likely contribute to the skills and networks of investigators necessary for the next generation of HIV investigators.