Cerebral sinus thrombosis in a child with active ulcerative colitis and factor V Leiden

Pediatr Blood Cancer. 2009 Jul;52(7):867-9. doi: 10.1002/pbc.21967.

Abstract

Ulcerative colitis (UC) is a rare cause of cerebral sinus thrombosis. We describe a 10-year-old patient with UC who developed cerebral sinus thrombosis during an acute exacerbation of his colitis and was found to be heterozygous for factor V Leiden. He was successfully treated with enoxaparin. Enoxaparin was then used for prophylaxis during acute exacerbations of his UC without any recurrence/progression of cerebral venous thrombosis. This report describes a cerebral thrombotic event in a child with UC and factor V Leiden.

Publication types

  • Case Reports

MeSH terms

  • Anticoagulants / therapeutic use
  • Child
  • Colitis, Ulcerative / complications*
  • Colitis, Ulcerative / drug therapy
  • Colitis, Ulcerative / genetics
  • Enoxaparin / therapeutic use
  • Factor V / genetics*
  • Heterozygote
  • Humans
  • Intracranial Thrombosis / drug therapy
  • Intracranial Thrombosis / etiology*
  • Intracranial Thrombosis / pathology
  • Magnetic Resonance Imaging
  • Male
  • Point Mutation / genetics*
  • Sinus Thrombosis, Intracranial / drug therapy
  • Sinus Thrombosis, Intracranial / etiology*
  • Sinus Thrombosis, Intracranial / pathology
  • Treatment Outcome

Substances

  • Anticoagulants
  • Enoxaparin
  • factor V Leiden
  • Factor V