Electronic medical records and personal health records have made good progress in reducing costs and inefficiencies, but the key to building a health care delivery system for the twenty-first century is to evolve toward personal health management systems that apply the full power of software to improve patient care. Such systems can enable better outcomes and improve the satisfaction of consumers and providers alike. Through technology innovation, sensible policy approaches, and industrywide collaboration, we can empower individuals to take control of their health while enabling providers and payers to broaden access to higher-quality, more affordable care.