Molecular mechanisms of propofol-involved suppression of no biosynthesis and inducible iNOS gene expression in LPS-stimulated macrophage-like raw 264.7 cells

Shock. 2010 Jan;33(1):93-100. doi: 10.1097/SHK.0b013e3181a6eaf5.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anesthetics, Intravenous / pharmacology*
  • Animals
  • Cell Line
  • Electrophoretic Mobility Shift Assay
  • Immunoblotting
  • Lipopolysaccharides / pharmacology*
  • MAP Kinase Kinase 4 / metabolism
  • Macrophages / drug effects*
  • Macrophages / enzymology
  • Macrophages / metabolism*
  • Mice
  • Mitogen-Activated Protein Kinase 8 / metabolism
  • Mitogen-Activated Protein Kinase 9 / metabolism
  • Nitric Oxide Synthase Type II / genetics
  • Nitric Oxide Synthase Type II / metabolism*
  • Nitrogen Oxides / metabolism*
  • Phosphorylation / drug effects
  • Polymerase Chain Reaction
  • Propofol / pharmacology*
  • RNA, Small Interfering
  • Toll-Like Receptor 4 / genetics
  • Toll-Like Receptor 4 / physiology

Substances

  • Anesthetics, Intravenous
  • Lipopolysaccharides
  • Nitrogen Oxides
  • RNA, Small Interfering
  • Tlr4 protein, mouse
  • Toll-Like Receptor 4
  • Nitric Oxide Synthase Type II
  • Nos2 protein, mouse
  • Mitogen-Activated Protein Kinase 9
  • Mitogen-Activated Protein Kinase 8
  • MAP Kinase Kinase 4
  • Propofol