Cardiovascular regeneration: pushing and pulling on progenitors

Matthew L Steinhauser; Richard T Lee

doi:10.1016/j.stem.2009.03.008

Cardiovascular regeneration: pushing and pulling on progenitors

Cell Stem Cell. 2009 Apr 3;4(4):277-8. doi: 10.1016/j.stem.2009.03.008.

Authors

Matthew L Steinhauser¹, Richard T Lee

Affiliation

¹ Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115-6110, USA.

PMID: 19341614
DOI: 10.1016/j.stem.2009.03.008

Abstract

In this issue of Cell Stem Cell, Zaruba et al. (2009) describe a pharmacoregenerative strategy for myocardial infarction. Using G-CSF to release progenitors from bone marrow and protease inhibition to prevent degradation of the homing signal, SDF-1, the authors achieve increased recruitment to the heart and improved heart function.

Publication types

Comment

MeSH terms

Animals
Cardiovascular System / metabolism
Cell Movement / physiology
Chemokine CXCL12 / metabolism*
Dipeptidyl Peptidase 4 / metabolism
Granulocyte Colony-Stimulating Factor / therapeutic use*
Hematopoietic Stem Cell Mobilization
Mice
Myocardial Infarction / drug therapy*
Myocardial Infarction / physiopathology
Neovascularization, Physiologic*
Receptors, CXCR4 / metabolism*
Regeneration / physiology*

Substances

CXCR4 protein, mouse
Chemokine CXCL12
Cxcl12 protein, mouse
Receptors, CXCR4
Granulocyte Colony-Stimulating Factor
Dipeptidyl Peptidase 4