Presence of messenger ribonucleic acid for epidermal growth factor (EGF) and EGF receptor demonstrable in monolayer cell cultures of myometria and leiomyomata

J Yeh; M Rein; R Nowak

doi:10.1016/s0015-0282(16)54681-0

Presence of messenger ribonucleic acid for epidermal growth factor (EGF) and EGF receptor demonstrable in monolayer cell cultures of myometria and leiomyomata

Fertil Steril. 1991 Nov;56(5):997-1000. doi: 10.1016/s0015-0282(16)54681-0.

Authors

J Yeh¹, M Rein, R Nowak

Affiliation

¹ Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Boston, Massachusetts 02115.

PMID: 1936340
DOI: 10.1016/s0015-0282(16)54681-0

Abstract

There is a paucity of data concerning the factors involved in the growth of uterine leiomyomata. The expression of mRNAs encoding EGF and the EGF receptor in myometrial and leiomyoma cultures suggest that EGF may be involved in the autocrine/paracrine regulation of human uterine leiomyomata and myometrial growth.

MeSH terms

Amino Acid Sequence
DNA / genetics
Epidermal Growth Factor / genetics*
ErbB Receptors / genetics*
Female
Humans
Leiomyoma / chemistry*
Molecular Sequence Data
Myometrium / chemistry*
Polymerase Chain Reaction
RNA, Messenger / analysis*
Transcription, Genetic
Tumor Cells, Cultured
Uterine Neoplasms / chemistry*

Substances

RNA, Messenger
Epidermal Growth Factor
DNA
ErbB Receptors