This article looks at two of the major issues associated with the development of condition-specific quality of life measures. The first issue is the process of conceptualization. The importance of conceptualization to developing sound questions and instruments is evaluated, and the need to utilize multiple perspectives in the conceptualization process is discussed. The second issue addressed is fundamentals of writing survey questions. Questions from a range of sexual function questionnaires are presented and discussed relative to seven basic guidelines associated with question and response category development.