Perineuritis in acute lyme neuroborreliosis

Muscle Nerve. 2009 Jun;39(6):851-4. doi: 10.1002/mus.21289.

Abstract

Perineuritis is an unusual cause of direct peripheral nerve injury. We describe the clinicopathologic features of a 56-year-old man with mononeuritis multiplex due to Lyme disease; sural nerve biopsy demonstrated florid perineuritis. Treatment with intravenous ceftriaxone resulted in marked neurologic improvement. This study supports the notion that perineuritis forms part of the pathogenesis in acute Lyme neuroborreliosis.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Arm / innervation
  • Arm / physiopathology
  • Axons / pathology
  • Biopsy
  • Ceftriaxone / therapeutic use
  • Chemotaxis, Leukocyte / immunology
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Leg / innervation
  • Leg / physiopathology
  • Lyme Neuroborreliosis / drug therapy
  • Lyme Neuroborreliosis / pathology*
  • Lyme Neuroborreliosis / physiopathology
  • Male
  • Methylprednisolone / therapeutic use
  • Middle Aged
  • Muscle Weakness / microbiology
  • Muscle Weakness / physiopathology
  • Neuritis / microbiology*
  • Neuritis / pathology*
  • Neuritis / physiopathology
  • Peripheral Nerves / immunology
  • Peripheral Nerves / microbiology*
  • Peripheral Nerves / pathology*
  • Sural Nerve / microbiology
  • Sural Nerve / pathology
  • Treatment Outcome
  • Wallerian Degeneration / immunology
  • Wallerian Degeneration / microbiology
  • Wallerian Degeneration / pathology

Substances

  • Anti-Bacterial Agents
  • Immunosuppressive Agents
  • Ceftriaxone
  • Methylprednisolone