Chromosome segregation: Ndc80 can carry the load

Ajit P Joglekar; Jennifer G DeLuca

doi:10.1016/j.cub.2009.04.014

Chromosome segregation: Ndc80 can carry the load

Curr Biol. 2009 May 26;19(10):R404-7. doi: 10.1016/j.cub.2009.04.014.

Authors

Ajit P Joglekar¹, Jennifer G DeLuca

Affiliation

¹ Department of Biology, University of North Carolina, Chapel Hill, NC 27599, USA.

PMID: 19467206
DOI: 10.1016/j.cub.2009.04.014

Abstract

Dynamic attachments between kinetochores and spindle microtubules are required for chromosome bi-orientation in mitosis. A new study provides biophysical insight into how the Ndc80 complex may contribute to the formation of these attachments.

MeSH terms

Chromosome Segregation*
Kinetochores / metabolism*
Microtubules / metabolism
Nuclear Proteins / genetics
Nuclear Proteins / metabolism*
Saccharomyces cerevisiae Proteins / genetics
Saccharomyces cerevisiae Proteins / metabolism*
Spindle Apparatus / metabolism

Substances

NDC80 protein, S cerevisiae
Nuclear Proteins
Saccharomyces cerevisiae Proteins

Grants and funding

K01 CA125051/CA/NCI NIH HHS/United States