Abstract
The cell's ability to sense and respond to DNA damage is critical to maintain homeostasis and prevent the development of cancer. Paradoxically, Economopoulou et al. recently reported that a DNA damage response protein, H2AX, promotes tumor growth and angiogenesis.
MeSH terms
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Animals
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Cell Hypoxia / physiology
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DNA Damage / physiology*
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Endothelial Cells / physiology
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Endothelium, Vascular / physiology
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Histones / genetics
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Histones / physiology*
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Humans
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Mice
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Neoplasms / blood supply*
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Neoplasms / pathology
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Neovascularization, Pathologic / metabolism*
Substances
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H2AX protein, human
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Histones