Objective: Report the case of induction of spermatogenesis with the aromatase inhibitor letrozole.
Design: Case report.
Setting: University Infertility center.
Patient(s): A 31-year-old man with primary infertility, normal volume azoospermia, normal follicle stimulating hormone (FSH) levels and pattern of nonobstructive azoospermia (NOA) on a testicular biopsy.
Intervention(s): The patient was given the aromatase inhibitor letrozole for 4 months and had repeated FSH, testosterone, LH levels, semen analyses, and finally a testicular biopsy.
Main outcome measure(s): Results of a testis biopsy.
Result(s): Testis biopsy showed normal spermatogenesis following 4 months of letrozole therapy.
Conclusion(s): This is the first case report on the use of letrozole to treat male infertility and the first case report on the induction of spermatogenesis in a man with NOA using any aromatase inhibitor.