Molecular targeting of cancer stem cells

Cell Stem Cell. 2009 Aug 7;5(2):125-6. doi: 10.1016/j.stem.2009.07.006.

Abstract

Cancer stem cells may be important targets for new anticancer drugs. In two recent articles in Cell Stem Cell, Jin et al. (2009) and Hoey et al. (2009) provide proof of principle for this idea in experimental models of solid tumors and leukemias, respectively.

Publication types

  • Comment

MeSH terms

  • Animals
  • Antibodies, Monoclonal / therapeutic use*
  • Antineoplastic Agents / therapeutic use*
  • Humans
  • Interleukin-3 Receptor alpha Subunit / antagonists & inhibitors*
  • Intracellular Signaling Peptides and Proteins
  • Membrane Proteins / antagonists & inhibitors*
  • Mice
  • Neoplasms / drug therapy
  • Neoplasms / therapy*
  • Neoplastic Stem Cells / drug effects*
  • Receptors, Notch / antagonists & inhibitors

Substances

  • Antibodies, Monoclonal
  • Antineoplastic Agents
  • Interleukin-3 Receptor alpha Subunit
  • Intracellular Signaling Peptides and Proteins
  • Membrane Proteins
  • Receptors, Notch
  • delta protein