Objective: To prepare Artemether-Iron Sucrose lipid nanoparticles and examine the characteristics of the nanoparticles.
Methods: The Artemether-Iron Sucrose lipid nanoparticles were prepared by film-dispersing and high-pressure homegenization technique using soybean phospholipid and soybean oil as matrix. The entrapment efficiency and drug loading capacity were determined by HPLC. The morphology was examined by transmission electron microscope and the mean particle size was measured by laser light scattering technique.
Results: The products were spherical and well distributed. The mean diameter was (161+/-17.4) nm with (85.1+/-0.83)% of entrapment efficiency and (5.3+/-0.2)% of drug loading. The in vitro release test showed that the Art-IS-NLC had good sustained release characteristics.
Conclusion: The preparation method of Art-IS-NLC is simple and feasible. The products are well distributed with a high entrapment efficiency.