A combined, rational approach towards inhibition of the MEK-ERK and mTOR pathways in pancreatic ductal adenocarcinoma: promise or deja vu?

Cancer Biol Ther. 2009 Oct;8(20):1902-3. doi: 10.4161/cbt.8.20.9810. Epub 2009 Oct 14.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Apoptosis / drug effects
  • Benzimidazoles / administration & dosage
  • Benzimidazoles / pharmacology
  • Carcinoma, Pancreatic Ductal / drug therapy*
  • Carcinoma, Pancreatic Ductal / metabolism
  • Carcinoma, Pancreatic Ductal / pathology
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Extracellular Signal-Regulated MAP Kinases / metabolism
  • Humans
  • Intracellular Signaling Peptides and Proteins / antagonists & inhibitors
  • Intracellular Signaling Peptides and Proteins / metabolism
  • Mice
  • Mice, Inbred NOD
  • Mice, SCID
  • Mitogen-Activated Protein Kinase Kinases / antagonists & inhibitors
  • Mitogen-Activated Protein Kinase Kinases / metabolism
  • Models, Biological
  • Pancreatic Neoplasms / drug therapy*
  • Pancreatic Neoplasms / metabolism
  • Pancreatic Neoplasms / pathology
  • Protein Serine-Threonine Kinases / antagonists & inhibitors
  • Protein Serine-Threonine Kinases / metabolism
  • Ribosomal Protein S6 / antagonists & inhibitors
  • Ribosomal Protein S6 / metabolism
  • Ribosomal Protein S6 Kinases / metabolism
  • Signal Transduction / drug effects*
  • Sirolimus / administration & dosage
  • Sirolimus / pharmacology
  • TOR Serine-Threonine Kinases
  • Xenograft Model Antitumor Assays*

Substances

  • AZD 6244
  • Benzimidazoles
  • Intracellular Signaling Peptides and Proteins
  • Ribosomal Protein S6
  • MTOR protein, human
  • mTOR protein, mouse
  • Protein Serine-Threonine Kinases
  • Ribosomal Protein S6 Kinases
  • TOR Serine-Threonine Kinases
  • Extracellular Signal-Regulated MAP Kinases
  • Mitogen-Activated Protein Kinase Kinases
  • Sirolimus