Advances in our understanding of the many levels of regulation of TGFbeta and BMP signaling were reported at the recent FASEB Summer Conference entitled ;The TGFbeta Superfamily: Development and Disease', which was held in Carefree, Arizona, USA, on the northern edge of the Sonoran Desert. This conference was the fifth meeting in a biannual FASEB conference series and, as with the previous meetings, brought together biochemists, geneticists, developmental and tissue biologists interested in the inter-workings of TGFbeta/BMP signaling pathways and in the consequences of these pathways going awry.