New chromosomal rearrangement, t(12;22)(p13;q12), in acute nonlymphocytic leukemia

D F Callen; Y J Hull; I R Toogood; T Fioretos; S Heim; N Mandahl; F Mitelman

doi:10.1016/0165-4608(91)90138-k

New chromosomal rearrangement, t(12;22)(p13;q12), in acute nonlymphocytic leukemia

Cancer Genet Cytogenet. 1991 Feb;51(2):255-8. doi: 10.1016/0165-4608(91)90138-k.

Authors

D F Callen¹, Y J Hull, I R Toogood, T Fioretos, S Heim, N Mandahl, F Mitelman

Affiliation

¹ Department of Cytogenetics and Molecular Genetics, Adelaide Children's Hospital, Australia.

PMID: 1993309
DOI: 10.1016/0165-4608(91)90138-k

Abstract

The karyotype 47,XX, + 8,t(12;22)(p13;q12) was found at diagnosis in two patients with acute nonlymphocytic leukemia (ANLL). The bone marrow morphology of both patients corresponded to the M4 subtype of the French-American-British (FAB) classification. The translocation t(12;22) has not previously been reported as the sole structural aberration in ANLL.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Child
Chromosomes, Human, Pair 12*
Chromosomes, Human, Pair 22*
Chromosomes, Human, Pair 8
Female
Gene Rearrangement*
Humans
Karyotyping
Leukemia, Myeloid, Acute / genetics*
Male
Trisomy