Endothelial progenitor cells in arthritis-associated vasculogenesis and atherosclerosis

Joint Bone Spine. 2009 Dec;76(6):581-3. doi: 10.1016/j.jbspin.2009.04.007.

Abstract

Vasculogenesis is the generation of vessels from endothelial progenitor cells (EPCs). Attenuated numbers and function of EPCs associated with defective vasculogenesis are present in rheumatoid arthritis (RA), scleroderma and other autoimmune-inflammatory diseases, which have significant relevance for increased cardio- and cerebrovascular morbidity and mortality in arthritis [–5]. Stimulation of EPCs and vasculogenesis may be beneficial to prevent and manage atherosclerosis related to arthritis. [–5].

Publication types

  • Editorial

MeSH terms

  • Antibodies, Monoclonal / administration & dosage
  • Arthritis, Rheumatoid / complications
  • Arthritis, Rheumatoid / physiopathology*
  • Arthritis, Rheumatoid / therapy
  • Atherosclerosis / complications
  • Atherosclerosis / physiopathology*
  • Atherosclerosis / therapy
  • Biomarkers / metabolism
  • Endothelium, Vascular / physiopathology*
  • Humans
  • Mesenchymal Stem Cell Transplantation
  • Mesenchymal Stem Cells / cytology*
  • Mesenchymal Stem Cells / physiology
  • Neovascularization, Pathologic / physiopathology*
  • Synovial Membrane / blood supply

Substances

  • Antibodies, Monoclonal
  • Biomarkers