Genome-wide association and linkage analysis of quantitative traits: comparison of likelihood-ratio test and conditional score statistic

BMC Proc. 2009 Dec 15;3 Suppl 7(Suppl 7):S100. doi: 10.1186/1753-6561-3-s7-s100.

Abstract

Over the past decade, genetic analysis has shifted from linkage studies, which identify broad regions containing putative trait loci, to genome-wide association studies, which detect the association of a marker with a specific phenotype. Because linkage and association analysis provide complementary information, developing a method to combine these analyses may increase the power to detect a true association. In this paper we compare a linkage score and association score test as well as a newly proposed combination of these two scores with traditional linkage and association methods.