Catechol-O-methyltransferase val108/158met genotype, major depressive disorder and response to selective serotonin reuptake inhibitors in major depressive disorder

Ari Illi; Eija Setälä-Soikkeli; Olli Kampman; Merja Viikki; Timo Nuolivirta; Outi Poutanen; Heini Huhtala; Nina Mononen; Terho Lehtimäki; Esa Leinonen

doi:10.1016/j.psychres.2009.03.010

Catechol-O-methyltransferase val108/158met genotype, major depressive disorder and response to selective serotonin reuptake inhibitors in major depressive disorder

Psychiatry Res. 2010 Mar 30;176(1):85-7. doi: 10.1016/j.psychres.2009.03.010. Epub 2010 Jan 13.

Authors

Ari Illi¹, Eija Setälä-Soikkeli, Olli Kampman, Merja Viikki, Timo Nuolivirta, Outi Poutanen, Heini Huhtala, Nina Mononen, Terho Lehtimäki, Esa Leinonen

Affiliation

¹ University of Tampere, Medical School, Tampere, Finland. ari.illi@uta.fi

PMID: 20071037
DOI: 10.1016/j.psychres.2009.03.010

Abstract

The functional val108/158met polymorphism of the COMT gene (rs4680) was evaluated in major depressive disorder (MDD), and in the treatment response to antidepressants in MDD. We could not demonstrate any significant difference in the distribution of this COMT single-nucleotide polymorphism (SNP) in the treatment response to selective serotonin reuptake inhibitors or between patients with MDD and control subjects.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catechol O-Methyltransferase / genetics*
Depressive Disorder, Major / drug therapy*
Depressive Disorder, Major / genetics*
Finland
Gene Frequency
Genome-Wide Association Study
Genotype
Humans
Methionine / genetics*
Pharmacogenetics
Polymorphism, Single Nucleotide
Selective Serotonin Reuptake Inhibitors / therapeutic use*
Valine / genetics*

Substances

Serotonin Uptake Inhibitors
Methionine
Catechol O-Methyltransferase
Valine