TRRAP and the maintenance of stemness in gliomas

Nikki A Charles; Eric C Holland

doi:10.1016/j.stem.2009.12.005

TRRAP and the maintenance of stemness in gliomas

Cell Stem Cell. 2010 Jan 8;6(1):6-7. doi: 10.1016/j.stem.2009.12.005.

Authors

Nikki A Charles¹, Eric C Holland

Affiliation

¹ Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

PMID: 20085736
DOI: 10.1016/j.stem.2009.12.005

Abstract

Resistance of brain tumors to therapy and their eventual recurrence is attributed to stem-like cells. In this issue of Cell Stem Cell, a high-throughput kinome-wide screen (Wurdak et al., 2010) has identified TRRAP, a kinase-related protein, as being required for stem cell character in gliomas.

Grants and funding

U54 CA126518/CA/NCI NIH HHS/United States