Continuous infusion of amphotericin B deoxycholate in the treatment of cryptococcal meningoencephalitis: analysis of safety and fungicidal activity

Clin Infect Dis. 2010 Mar 1;50(5):e26-9. doi: 10.1086/650489.

Abstract

We measured fungicidal activity of continuous infusion of amphotericin B deoxycholate plus 5'flucytosine using quantitative cultures of cerebrospinal fluid (CSF) obtained from lumbar punctures of human immunodeficiency virus (HIV)-infected patients with neurocryptococcosis during 14 days of treatment. Glomerular renal function was preserved in all patients. Mycological efficacy with progressive reduction in CSF cryptococcal colony-forming units was comparable to standard 4-h infusion of amphotericin B.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Amphotericin B / administration & dosage*
  • Amphotericin B / therapeutic use*
  • Antifungal Agents / administration & dosage*
  • Antifungal Agents / therapeutic use*
  • Cerebrospinal Fluid / microbiology
  • Colony Count, Microbial
  • Cryptococcus / drug effects
  • Cryptococcus / isolation & purification
  • Deoxycholic Acid / administration & dosage*
  • Deoxycholic Acid / therapeutic use*
  • Drug Combinations
  • Female
  • Flucytosine / administration & dosage
  • Flucytosine / therapeutic use
  • HIV Infections / complications
  • Humans
  • Infusions, Intravenous
  • Male
  • Meningitis, Cryptococcal / drug therapy*
  • Meningitis, Cryptococcal / microbiology
  • Microbial Viability / drug effects
  • Middle Aged
  • Treatment Outcome
  • Young Adult

Substances

  • Antifungal Agents
  • Drug Combinations
  • Deoxycholic Acid
  • Amphotericin B
  • amphotericin B, deoxycholate drug combination
  • Flucytosine