Leech-derived thrombin inhibitors: from structures to mechanisms to clinical applications

J Med Chem. 2010 May 27;53(10):3847-61. doi: 10.1021/jm901743x.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Factor Xa Inhibitors
  • Fibrinolytic Agents* / chemical synthesis
  • Fibrinolytic Agents* / chemistry
  • Fibrinolytic Agents* / pharmacology
  • Hirudins* / chemical synthesis
  • Hirudins* / chemistry
  • Hirudins* / pharmacology
  • Invertebrate Hormones / chemistry
  • Invertebrate Hormones / pharmacology
  • Leeches / chemistry*
  • Models, Molecular
  • Molecular Sequence Data
  • Proteins / chemistry
  • Proteins / pharmacology
  • Thrombin / antagonists & inhibitors*

Substances

  • Factor Xa Inhibitors
  • Fibrinolytic Agents
  • Hirudins
  • Invertebrate Hormones
  • Proteins
  • haemadin
  • therostasin protein, Theromyzon tessulatum
  • antistasin
  • Thrombin