Evidence for sensory neuropathy and pharmacologic management

Otolaryngol Clin North Am. 2010 Feb;43(1):67-72, viii. doi: 10.1016/j.otc.2009.11.003.

Abstract

Recent literature points to postviral sensory neuropathy as a possible cause for refractory chronic cough. Vagal neuropathy may affect the sensory branches, inducing chronic cough or laryngospasm. Although the clinical presentation is fairly well described, there is little in the way of diagnostic criteria to establish this diagnosis. This article highlights the clinical picture of this disease and the efficacy, side-effect profiles of the currently used pharmacological interventions.

Publication types

  • Review

MeSH terms

  • Adrenergic Uptake Inhibitors / therapeutic use
  • Amines / therapeutic use
  • Amitriptyline / therapeutic use
  • Anticonvulsants / therapeutic use
  • Chronic Disease
  • Cough / drug therapy
  • Cough / etiology
  • Cough / physiopathology
  • Cyclohexanecarboxylic Acids / therapeutic use
  • Gabapentin
  • Humans
  • Pregabalin
  • Vagus Nerve Diseases / drug therapy*
  • Vagus Nerve Diseases / etiology*
  • Vagus Nerve Diseases / physiopathology
  • Virus Diseases / complications
  • gamma-Aminobutyric Acid / analogs & derivatives
  • gamma-Aminobutyric Acid / therapeutic use

Substances

  • Adrenergic Uptake Inhibitors
  • Amines
  • Anticonvulsants
  • Cyclohexanecarboxylic Acids
  • Amitriptyline
  • Pregabalin
  • gamma-Aminobutyric Acid
  • Gabapentin