The contribution of the Epstein-Barr virus to the pathogenesis of childhood lymphomas

Cancer Treat Rev. 2010 Jun;36(4):348-53. doi: 10.1016/j.ctrv.2010.02.011. Epub 2010 Mar 2.

Abstract

The Epstein-Barr virus (EBV) is a lymphotropic herpes virus with oncogenetic properties which can lead to the development of lymphomas such as Burkitt's lymphoma (BL), Hodgkin's lymphoma (HL), or post-transplant lymphoma. This review discusses our current understanding of lymphomagenesis in relation to EBV and the potential for targeted therapies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antiviral Agents / therapeutic use
  • Burkitt Lymphoma / etiology
  • Burkitt Lymphoma / virology
  • Child
  • Herpesvirus 4, Human / isolation & purification*
  • Hodgkin Disease / etiology
  • Hodgkin Disease / virology
  • Humans
  • Immunotherapy, Adoptive
  • Lymphoma / etiology*
  • Lymphoma / virology
  • Lymphoma, B-Cell / etiology
  • Lymphoma, B-Cell / virology
  • Lymphoproliferative Disorders / etiology
  • Lymphoproliferative Disorders / virology

Substances

  • Antiviral Agents