Concise total synthesis of (+/-)-lycopladine A

Org Lett. 2010 Apr 2;12(7):1576-9. doi: 10.1021/ol100273p.

Abstract

A concise total synthesis of the Lycopodium alkaloid lycopladine A (1) is described that features sequential conjugate addition and enolate arylation reactions to construct the tricyclic core in two steps.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Crystallography, X-Ray
  • Lycopodium / chemistry
  • Models, Molecular
  • Molecular Structure
  • Sesquiterpenes / chemical synthesis*
  • Sesquiterpenes / chemistry
  • Stereoisomerism

Substances

  • Sesquiterpenes
  • lycopladine A