Abstract
A 59-year-old woman with von Hippel-Lindau disease developed erythrocytosis and a recurrent intracranial hemangioblastoma. Radioimmunoassay showed an elevated level of erythropoietin in her serum. Cyst fluid from the tumor also contained erythropoietin, concentrated a thousandfold relative to the serum level. Production of erythropoietin by hemangioblastomas may explain the erythrocytosis present in some patients with von Hippel-Lindau disease.
MeSH terms
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Brain Neoplasms / complications*
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Brain Neoplasms / pathology
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Brain Neoplasms / physiopathology
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Brain Stem / pathology*
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Erythropoietin / analysis*
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Female
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Hemangiosarcoma / complications*
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Hemangiosarcoma / pathology
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Hemangiosarcoma / physiopathology
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Humans
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Magnetic Resonance Imaging
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Middle Aged
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Polycythemia / complications*
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Polycythemia / physiopathology
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Radioimmunoassay
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von Hippel-Lindau Disease / complications*
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von Hippel-Lindau Disease / pathology
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von Hippel-Lindau Disease / physiopathology