Abstract
We investigated the impact of a congenital prefrontal lesion and its resection on decision making under risk and under ambiguity in a patient with right mediofrontal cortical dysplasia. Both kinds of decision making are normally associated with the medial prefrontal cortex. We additionally studied pre- and postsurgical fMRI activations when processing information relevant for risky decision making. Results indicate selective impairments of ambiguous decision making pre- and postsurgically. Decision making under risk was intact. In contrast to healthy subjects the patient exhibited no activation within the dysplastic anterior cingulate cortex but left-sided orbitofrontal activation on the fMRI task suggesting early reorganization processes.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Attention / physiology
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Brain Mapping*
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Carbamide Peroxide
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Cognition Disorders / etiology*
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Decision Making / physiology*
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Executive Function / physiology
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Female
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Frontal Lobe / blood supply
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Frontal Lobe / physiopathology*
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Functional Laterality / physiology
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Humans
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Image Processing, Computer-Assisted / methods
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Intelligence
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Magnetic Resonance Imaging / methods
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Malformations of Cortical Development / complications*
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Malformations of Cortical Development / pathology
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Malformations of Cortical Development / surgery
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Memory / physiology
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Middle Aged
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Neuropsychological Tests
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Pattern Recognition, Visual / physiology
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Peroxides / blood
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Photic Stimulation
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Treatment Outcome
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Urea / analogs & derivatives
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Urea / blood
Substances
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Peroxides
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Carbamide Peroxide
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Urea