Ozone activates pulmonary dendritic cells and promotes allergic sensitization through a Toll-like receptor 4-dependent mechanism

J Allergy Clin Immunol. 2010 May;125(5):1167-70. doi: 10.1016/j.jaci.2010.03.001. Epub 2010 Apr 15.

Abstract

Human exposure to ozone is associated with increased prevalence of allergic asthma. Here, we demonstrate that ozone increases levels of activated dendritic cells in thoracic lymph nodes and promotes allergic sensitization through a TLR4-dependent pathway.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural

MeSH terms

  • Air Pollutants / adverse effects
  • Air Pollutants / immunology*
  • Animals
  • Dendritic Cells / drug effects
  • Dendritic Cells / immunology*
  • Dendritic Cells / metabolism
  • Lung / cytology
  • Lung / immunology*
  • Mice
  • Mice, Inbred C57BL
  • Ozone / adverse effects
  • Ozone / immunology*
  • Respiratory Hypersensitivity* / etiology
  • Respiratory Hypersensitivity* / immunology
  • Respiratory Hypersensitivity* / physiopathology
  • Toll-Like Receptor 4 / deficiency
  • Toll-Like Receptor 4 / genetics
  • Toll-Like Receptor 4 / metabolism*

Substances

  • Air Pollutants
  • Toll-Like Receptor 4
  • Ozone