HIV-1 assembly at the plasma membrane

Akira Ono

doi:10.1016/j.vaccine.2009.10.021

HIV-1 assembly at the plasma membrane

Vaccine. 2010 May 26:28 Suppl 2:B55-9. doi: 10.1016/j.vaccine.2009.10.021.

Author

Akira Ono¹

Affiliation

¹ Department of Microbiology and Immunology, University of Michigan Medical School, 5736 Medical Science Building II, 1150 W Medical Center Drive, Ann Arbor, MI 48109-0620, United States. akiraono@umich.edu

Abstract

HIV-1 particle assembly takes place at the plasma membrane, which likely enhances release of extracellular virions and spread to next target cells. Recent work by our lab and others started to reveal a molecular mechanism by which HIV ensures to make the plasma membrane as a primary site of virus assembly.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Cell Membrane / virology*
HIV-1 / physiology*
Phosphatidylinositol 4,5-Diphosphate / metabolism
Virus Assembly*
gag Gene Products, Human Immunodeficiency Virus / metabolism

Substances

Phosphatidylinositol 4,5-Diphosphate
gag Gene Products, Human Immunodeficiency Virus

Grants and funding

R01 AI071727/AI/NIAID NIH HHS/United States