Few instruments have been translated and validated for people who use American Sign Language (ASL) as their preferred language. This study examined the reliability and validity of a new ASL version of the widely used Multidimensional Health Locus of Control (MHLC) scales. Deaf individuals (N = 311) were shown the ASL version via videotape, and their responses were recorded. Confirmatory factor analysis supported the four-factor structure of the MHLC. Scale reliabilities (Cronbach's alphas) ranged from 0.60 to 0.93. There were no apparent gender or ethnic differences. These results provide support for the new ASL version of the MHLC scales.