Mitochondrial biogenesis: sorting mechanisms cooperate in ABC transporter assembly

Chaille T Webb; Trevor Lithgow

doi:10.1016/j.cub.2010.05.024

Mitochondrial biogenesis: sorting mechanisms cooperate in ABC transporter assembly

Curr Biol. 2010 Jul 13;20(13):R564-7. doi: 10.1016/j.cub.2010.05.024.

Authors

Chaille T Webb¹, Trevor Lithgow

Affiliation

¹ Department of Biochemistry & Molecular Biology, Monash University, Clayton Campus, Melbourne 3800, Australia.

PMID: 20619810
DOI: 10.1016/j.cub.2010.05.024

Abstract

The assembly of proteins into the mitochondrial inner membrane had been thought to occur via several distinct pathways. A new study challenges this view and shows that the mitochondrial ABC transporter Mdl1 is assembled into the inner membrane in a modular fashion by two different pieces of machinery.

MeSH terms

ATP-Binding Cassette Transporters / chemistry
ATP-Binding Cassette Transporters / metabolism*
Intracellular Membranes / metabolism
Mitochondria / metabolism*
Models, Molecular

Substances

ATP-Binding Cassette Transporters