[Comparative study of the toxicity of cyanic derivatives and/or aromatic amides]

Ann Pharm Fr. 1990;48(1):23-31.
[Article in French]

Abstract

The toxical potentiality of the cyanic radicle and the detoxicating characteristic of the amide group are studied following the evolution of the benzonitrile and benzamide toxicity when a cyanic or amide radicle is added to the original molecule. This comparative study shows that the presence of amide group has not always given a higher toxicity to the organic molecules that own it. It is the respective localization of the cyanic or amide radicles which appears to play the most important role.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Animals
  • Benzamides / administration & dosage
  • Benzamides / toxicity*
  • Drug Administration Schedule
  • Female
  • Infusions, Intravenous
  • Male
  • Mice
  • Nitriles / administration & dosage
  • Nitriles / toxicity*
  • Rats
  • Rats, Inbred Strains
  • Time Factors

Substances

  • Benzamides
  • Nitriles
  • benzonitrile