A model of host response to a multi-stage pathogen

J Math Biol. 2011 Aug;63(2):201-27. doi: 10.1007/s00285-010-0365-5. Epub 2010 Oct 2.

Abstract

We model the immune surveillance of a pathogen which passes through n immunologically distinct stages. The biological parameters of this system induce a partial order on the stages, and this, in turn, determines which stages will be subject to immune regulation. This corresponds to the system's unique asymptotically stable fixed point.

MeSH terms

  • Animals
  • Epstein-Barr Virus Infections / immunology
  • Epstein-Barr Virus Infections / virology
  • Herpesvirus 4, Human / immunology
  • Host-Pathogen Interactions / immunology*
  • Models, Immunological*