[A study on the correlation between P-selectin and lung cancer]

X Xu; Q Li; J Yang; X Li; S Gao

doi:10.3779/j.issn.1009-3419.1999.02.04

[A study on the correlation between P-selectin and lung cancer]

Zhongguo Fei Ai Za Zhi. 1999 Dec 25;2(2):74-6. doi: 10.3779/j.issn.1009-3419.1999.02.04.

[Article in Chinese]

Authors

X Xu¹, Q Li, J Yang, X Li, S Gao

Affiliation

¹ Department of Respiratory Disease , 1st Affiliated Hospital of Hubei Medical University , Wuhan , Hubei 430060 , P. R. China.

PMID: 20929633
DOI: 10.3779/j.issn.1009-3419.1999.02.04

Abstract

Background: To investigate the role of P-selectin in metastasis of lung cancer.

Methods: Expression of P-selectin were examined in 48 primary lung cancer specimens by the microware enhanced immunohistochemical staining method (SP) using a rat monoclonal antibody against human P-selectin , with 18 cases of adjacent non-cancerous tissue as control.

Results: The positive rate of P-selectin expression in adenocarcinoma was significantly higher than those of squamous cell carcinoma and adjacent non-cancerous tissues ( P < 0. 01) . In adenocarcinoma , the expression of P-selectin in stage III and IV was significantly higher than that of stage I and II ( P < 0. 01) .But there were no significant correlation between the expression of P-selectin and differentiation grade of tumor , lymph node metastasis , size of the primary tumor.

Conclusions: P-selectin might be associated with vascular metastasis in adenocarcinoma.

Publication types

English Abstract