Stem cell fate in proliferating tissues: equal odds in a game of chance

Philip H Jones

doi:10.1016/j.devcel.2010.10.001

Stem cell fate in proliferating tissues: equal odds in a game of chance

Dev Cell. 2010 Oct 19;19(4):489-90. doi: 10.1016/j.devcel.2010.10.001.

Author

Philip H Jones¹

Affiliation

¹ MRC Cancer Cell Unit, Hutchison-MRC Research Centre, Addenbrooke's Hospital, Cambridge CB2 0XZ, UK. phj20@hutchison-mrc.cam.ac.uk

PMID: 20951341
DOI: 10.1016/j.devcel.2010.10.001

Abstract

Quantitative lineage tracing reveals stem cell fate in vivo. A new study in a recent issue of Cell shows intestinal crypt stem cells are functionally equivalent, with equal odds of differentiation. Differentiating stem cells are replaced by the symmetric division of adjacent stem cells.

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