Rapid haplotype inference for nuclear families

Genome Biol. 2010;11(10):R108. doi: 10.1186/gb-2010-11-10-r108. Epub 2010 Oct 29.

Abstract

Hapi is a new dynamic programming algorithm that ignores uninformative states and state transitions in order to efficiently compute minimum-recombinant and maximum likelihood haplotypes. When applied to a dataset containing 103 families, Hapi performs 3.8 and 320 times faster than state-of-the-art algorithms. Because Hapi infers both minimum-recombinant and maximum likelihood haplotypes and applies to related individuals, the haplotypes it infers are highly accurate over extended genomic distances.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Algorithms*
  • Computational Biology / methods*
  • Databases, Genetic
  • Gene Conversion
  • Genetic Loci
  • Genotype
  • Haplotypes*
  • Humans
  • Likelihood Functions
  • Models, Genetic
  • Nuclear Family
  • Pedigree
  • Polymorphism, Single Nucleotide
  • Software