Abstract
A library of triazole-based telomeric quadruplex-selective ligands has been developed that mimic an established family of tri-substituted acridine-based ligands, using crystal structure data as a starting-point for computer-based design. Binding affinities, estimated by electrospray mass spectrometry, are in accord with the design concept.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acridines
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Computer Simulation
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Drug Design
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G-Quadruplexes*
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Ligands
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Small Molecule Libraries
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Spectrometry, Mass, Electrospray Ionization
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Structure-Activity Relationship
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Telomere / chemistry*
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Triazoles / chemistry*
Substances
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Acridines
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Ligands
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Small Molecule Libraries
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Triazoles