Transforming growth factor-beta and ovarian carcinoma cells: regulation of proliferation and surface antigen expression

Cancer Lett. 1990 Jun 15;51(3):221-5. doi: 10.1016/0304-3835(90)90106-8.

Abstract

Transforming growth factor-beta (TGF-beta) is a multifunctional peptide regulating several processes in ovarian cells. The growth of ovarian carcinoma cell lines (OVCAR-3, HTB-77, 2780 and CRL-1572) was reduced by TGF-beta in a dose related manner. The antiproliferative activity was not improved by combination with other biological response modifiers. Treatment with TGF-beta augmented the expression of interferon-gamma induced class I and II antigens of the major histocompatibility complex. The presentation of another antigen namely the tumor marker CA-125 on the cell surface was markedly reduced by TGF-beta.

MeSH terms

  • Antigens, Neoplasm / analysis*
  • Antigens, Surface / analysis*
  • Cell Division / drug effects
  • Cell Survival / drug effects
  • Female
  • Humans
  • Interferon-gamma / antagonists & inhibitors
  • Major Histocompatibility Complex / drug effects
  • Ovarian Neoplasms / immunology
  • Ovarian Neoplasms / pathology*
  • Recombinant Proteins / pharmacology
  • Transforming Growth Factors / pharmacology*
  • Tumor Cells, Cultured / drug effects

Substances

  • Antigens, Neoplasm
  • Antigens, Surface
  • Recombinant Proteins
  • Transforming Growth Factors
  • Interferon-gamma