[Effects of hypothyroidism on Goalpha gene expression in hippocampus and dentate gyrus during early development of rat brain]

Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2001 Feb;17(1):21-4.
[Article in Chinese]

Abstract

Aim: To study the expression of Goalpha mRNA in hippocampus and dentate gyrus of 7-day rats with hypothyroidism.

Methods: We use wistar rat model of hypothyroidism and non-radioactive in situ hybridization technique to observe the changs of Goalpha mRNA levels in hippocampus and dentate gyrus of 7-day rats with or without hypothyroidism.

Results: Perinatal hypothyroidism can increase Goalpha mRNA levels in all areas of hippocampus and dentate gyrus of 7-day rats.

Conclusion: Thyroid hormone can down-regulate Goalpha gene transcription in hippocampus and dentate gyrus during the early development of rat brain.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Animals, Newborn
  • Dentate Gyrus / metabolism*
  • Female
  • GTP-Binding Protein alpha Subunits / genetics
  • GTP-Binding Protein alpha Subunits / metabolism*
  • Gene Expression Regulation, Developmental
  • Hippocampus / metabolism*
  • Hypothyroidism / genetics
  • Hypothyroidism / metabolism*
  • In Situ Hybridization
  • Pregnancy
  • RNA, Messenger / genetics*
  • Rats
  • Rats, Wistar
  • Thyroid Hormones / metabolism

Substances

  • GTP-Binding Protein alpha Subunits
  • RNA, Messenger
  • Thyroid Hormones
  • olfactory G protein subunit alpha olf