Abstract
Mitochondrial dysfunction and oxidative stress are thought to play important roles in mammalian aging. Resveratrol is a plant-derived polyphenol that exerts diverse antiaging activities, mimicking some of the molecular and functional effects of dietary restriction. This review focuses on the molecular mechanisms underlying the mitochondrial protective effects of resveratrol, which could be exploited for the prevention or amelioration of age-related diseases in the elderly.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, N.I.H., Intramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Aging / drug effects
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Animals
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Antioxidants / pharmacology*
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Caloric Restriction
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Humans
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Mice
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Mitochondria / drug effects*
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NF-E2-Related Factor 2 / physiology
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Oxidative Stress / drug effects*
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Resveratrol
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Sirtuin 1 / physiology
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Stilbenes / pharmacology*
Substances
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Antioxidants
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NF-E2-Related Factor 2
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Stilbenes
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Sirtuin 1
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Resveratrol