Abstract
The association of muscle tyrosine kinase (Musk) antibody with recurrent bulbar weakness in acetylcholine receptor antibody (Ach-R Ab) negative myasthenia gravis (MG) has been well documented. We describe 2 patients, a middle aged man and a 9-year-old girl, both seronegative for Ach R antibody who had recurrent bulbar weakness and MUSK antibody positivity. Patients made a full recovery from the acute episode with intravenous immunoglobulin (IV Ig) therapy. The peculiar clinical features of this condition and its management are discussed.
MeSH terms
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Amoxicillin / therapeutic use
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Anti-Bacterial Agents / therapeutic use
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Antibodies / blood*
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Autoantibodies / immunology
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Autoantibodies / therapeutic use
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Child
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Clavulanic Acid / therapeutic use
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Facial Muscles / pathology
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Female
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Humans
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Immunoglobulins, Intravenous / therapeutic use
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Male
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Middle Aged
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Muscle Weakness / etiology
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Muscle Weakness / immunology
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Muscular Atrophy / etiology
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Myasthenia Gravis / immunology*
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Myasthenia Gravis / pathology
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Myasthenia Gravis / therapy
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Receptor Protein-Tyrosine Kinases / metabolism*
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Receptors, Cholinergic / metabolism*
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Treatment Outcome
Substances
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Anti-Bacterial Agents
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Antibodies
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Autoantibodies
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Immunoglobulins, Intravenous
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Receptors, Cholinergic
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Clavulanic Acid
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Amoxicillin
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MUSK protein, human
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Receptor Protein-Tyrosine Kinases