Experience with patients with anti-MUSK antibody positive myasthenia gravis

J Assoc Physicians India. 2010 Oct:58:640-2.

Abstract

The association of muscle tyrosine kinase (Musk) antibody with recurrent bulbar weakness in acetylcholine receptor antibody (Ach-R Ab) negative myasthenia gravis (MG) has been well documented. We describe 2 patients, a middle aged man and a 9-year-old girl, both seronegative for Ach R antibody who had recurrent bulbar weakness and MUSK antibody positivity. Patients made a full recovery from the acute episode with intravenous immunoglobulin (IV Ig) therapy. The peculiar clinical features of this condition and its management are discussed.

Publication types

  • Case Reports

MeSH terms

  • Amoxicillin / therapeutic use
  • Anti-Bacterial Agents / therapeutic use
  • Antibodies / blood*
  • Autoantibodies / immunology
  • Autoantibodies / therapeutic use
  • Child
  • Clavulanic Acid / therapeutic use
  • Facial Muscles / pathology
  • Female
  • Humans
  • Immunoglobulins, Intravenous / therapeutic use
  • Male
  • Middle Aged
  • Muscle Weakness / etiology
  • Muscle Weakness / immunology
  • Muscular Atrophy / etiology
  • Myasthenia Gravis / immunology*
  • Myasthenia Gravis / pathology
  • Myasthenia Gravis / therapy
  • Receptor Protein-Tyrosine Kinases / metabolism*
  • Receptors, Cholinergic / metabolism*
  • Treatment Outcome

Substances

  • Anti-Bacterial Agents
  • Antibodies
  • Autoantibodies
  • Immunoglobulins, Intravenous
  • Receptors, Cholinergic
  • Clavulanic Acid
  • Amoxicillin
  • MUSK protein, human
  • Receptor Protein-Tyrosine Kinases