Abstract
In neonatal rat ventricular myocytes pretreatment with pertussis toxin did not affect 1 microM (-)-norepinephrine stimulation of inositol phosphates or myocardial cell hypertrophy as measured either by protein radiolabelling or by myocardial cell protein content. Thus guanine nucleotide protein(s) ADP-ribosylated by pertussis toxin do not play a role in two alpha 1-adrenoceptor-mediated processes, phosphatidylinositide turnover and induction of myocardial cell hypertrophy.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Adenosine Diphosphate Ribose / metabolism
-
Animals
-
Animals, Newborn / metabolism*
-
Cell Division
-
Cells, Cultured
-
Inositol Phosphates / metabolism
-
Myocardium / cytology
-
Myocardium / metabolism*
-
Norepinephrine / pharmacology*
-
Pertussis Toxin*
-
Phosphatidylinositols / metabolism*
-
Prazosin / analogs & derivatives
-
Prazosin / pharmacology
-
Propranolol / pharmacology
-
Rats
-
Receptors, Adrenergic, alpha / physiology*
-
Virulence Factors, Bordetella / pharmacology*
-
Yohimbine / pharmacology
Substances
-
Inositol Phosphates
-
Phosphatidylinositols
-
Receptors, Adrenergic, alpha
-
Virulence Factors, Bordetella
-
Adenosine Diphosphate Ribose
-
Yohimbine
-
Terazosin
-
Propranolol
-
Pertussis Toxin
-
Norepinephrine
-
Prazosin