β-Cyclodextrin conjugated magnetic nanoparticles for diazepam removal from blood

Chem Commun (Camb). 2011 Jul 21;47(27):7719-21. doi: 10.1039/c1cc11855b. Epub 2011 Jun 7.

Abstract

β-CD conjugated magnetic nanoparticles that serve as a hemoadsorbent for diazepam removal are fabricated. The diazepam is arrested by the conjugated β-CD and then the adsorbed diazepam is efficiently removed by an external magnetic field. These particles have potential applications in hemoperfusion or separation of other toxins and drugs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adsorption
  • Anti-Anxiety Agents / blood
  • Anti-Anxiety Agents / isolation & purification*
  • Diazepam / blood
  • Diazepam / isolation & purification*
  • Humans
  • Magnetics / methods*
  • Nanoparticles / chemistry*
  • Nanoparticles / ultrastructure
  • beta-Cyclodextrins / chemistry*

Substances

  • Anti-Anxiety Agents
  • beta-Cyclodextrins
  • betadex
  • Diazepam