Oseltamivir and risk of lower respiratory tract complications in patients with flu symptoms: a meta-analysis of eleven randomized clinical trials

Clin Infect Dis. 2011 Aug 1;53(3):277-9. doi: 10.1093/cid/cir400. Epub 2011 Jun 15.

Abstract

An independent reanalysis of 11 randomized clinical trials shows that oseltamivir treatment reduces the risk of lower respiratory tract complications requiring antibiotic treatment by 28% overall (95% confidence interval [CI], 11%-42%) and by 37% among patients with confirmed influenza infections (95% CI, 18%-52%).

Publication types

  • Meta-Analysis
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antiviral Agents / administration & dosage*
  • Female
  • Humans
  • Influenza, Human / complications*
  • Influenza, Human / drug therapy*
  • Male
  • Middle Aged
  • Oseltamivir / administration & dosage*
  • Pneumonia, Bacterial / epidemiology*
  • Pneumonia, Bacterial / prevention & control*
  • Randomized Controlled Trials as Topic
  • Risk Assessment
  • Young Adult

Substances

  • Antiviral Agents
  • Oseltamivir