Biomarkers and evolution in Alzheimer disease

Prog Neurobiol. 2011 Dec;95(4):510-3. doi: 10.1016/j.pneurobio.2011.07.006. Epub 2011 Jul 23.

Abstract

Brain regions and their highly neuroplastic long axonal connections that expanded rapidly during hominid evolution are preferentially affected by Alzheimer disease. There is no natural animal model with full disease pathology (neurofibrillary tangles and neuritic amyloid plaques of a severity seen in Alzheimer's disease brains). Biomarkers such as reduced glucose metabolism in association neocortex, defects in long white matter tracts, RNA neurochemical changes, and high CSF levels of total and phosphorylated tau protein, which are helpful to identify MCI and preclinical Alzheimer disease patients, may also provide insights into what brain changes led to this disease being introduced during hominid evolution.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural

MeSH terms

  • Alzheimer Disease* / cerebrospinal fluid
  • Alzheimer Disease* / complications
  • Alzheimer Disease* / diagnosis
  • Amyloid beta-Peptides / cerebrospinal fluid
  • Animals
  • Biological Evolution*
  • Biomarkers / cerebrospinal fluid*
  • Humans
  • Neurofibrillary Tangles / pathology
  • Plaque, Amyloid / etiology

Substances

  • Amyloid beta-Peptides
  • Biomarkers