Abstract
Regulatory mechanisms to prevent centriole overduplication during the cell cycle are not completely understood. In this issue, FBXW5 is shown to control the degradation of the centriole assembly factor HsSAS-6. Moreover, the study proposes that FBXW5 is a substrate of both PLK4 and APC/C, two established regulators of centriole duplication.
MeSH terms
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Anaphase-Promoting Complex-Cyclosome
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Animals
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Cell Cycle / physiology
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Cell Cycle Proteins / physiology
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Centrioles / physiology
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Centrosome / physiology*
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F-Box Proteins / physiology*
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Humans
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Models, Biological
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Protein Serine-Threonine Kinases / physiology
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Ubiquitin-Protein Ligase Complexes / physiology
Substances
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Cell Cycle Proteins
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F-Box Proteins
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FBXW5 protein, human
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SASS6 protein, human
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Ubiquitin-Protein Ligase Complexes
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Anaphase-Promoting Complex-Cyclosome
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PLK4 protein, human
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Protein Serine-Threonine Kinases