Epidemiological studies of Beijing strains of Mycobacterium tuberculosis from Taipei and other Asian cities based on MIRU profiles

APMIS. 2011 Sep;119(9):581-587. doi: 10.1111/j.1600-0463.2011.02790.x. Epub 2011 Jul 5.

Abstract

The aim of the present study was to investigate the distribution of the Beijing strains of Mycobacterium tuberculosis (MTB) in Taipei and other Asian cities. A total of 323 MTB isolates were analyzed by spacer oligonucleotide typing (spoligotyping) and mycobacterial interspersed repetitive unit (MIRU) typing. The largest cluster of the TB isolates from Taipei was type MT11 (MIRU type 2233-2517-3533). A comparison of the MIRU type data for the Beijing strains from Taipei and previously published MIRU type data for the Beijing strains from Asian cities with major population of Chinese was analyzed. The six major Beijing MIRU types (MT01, MT02, MT08, MT11, MT21, and MT44) were found to be common in four Asian cities including Taipei, Singapore, Hong Kong, and Wuhan. Results of this study indicate that there is geographical difference in the distribution of different Beijing strains of MTB.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Typing Techniques / methods*
  • DNA, Bacterial / analysis
  • DNA, Bacterial / genetics
  • Epidemiologic Studies
  • Genetic Loci
  • Genetic Variation
  • Genotype
  • Hong Kong / epidemiology
  • Humans
  • Mycobacterium tuberculosis / classification
  • Mycobacterium tuberculosis / genetics
  • Mycobacterium tuberculosis / isolation & purification*
  • Polymerase Chain Reaction / methods
  • Singapore / epidemiology
  • Taiwan / epidemiology
  • Tuberculosis / epidemiology*
  • Tuberculosis / microbiology

Substances

  • DNA, Bacterial