Screening newborns for primary T-cell immunodeficiencies: consensus and controversy

Deborah J Accetta Pedersen; James Verbsky; John M Routes

doi:10.1586/eci.11.25

Screening newborns for primary T-cell immunodeficiencies: consensus and controversy

Expert Rev Clin Immunol. 2011 Nov;7(6):761-8. doi: 10.1586/eci.11.25.

Authors

Deborah J Accetta Pedersen¹, James Verbsky, John M Routes

Affiliation

¹ Department of Pediatrics, Medical College of Wisconsin and Children's Research Institute, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

PMID: 22014017
DOI: 10.1586/eci.11.25

Abstract

Newborn screening for early identification of T-cell lymphopenia and severe combined immunodeficiency has recently been recommended as an addition to the newborn screening programs in all states. This article will review the evidence supporting the use of this newborn screening test, and will outline the barriers to nationwide implementation, which include issues specific to this test and controversies regarding newborn screening in general.

MeSH terms

Common Variable Immunodeficiency / diagnosis*
Common Variable Immunodeficiency / epidemiology
Consensus*
Female
Humans
Infant, Newborn
Infant, Newborn, Diseases / diagnosis*
Infant, Newborn, Diseases / epidemiology
Lymphopenia / diagnosis*
Male
National Health Programs / organization & administration
National Health Programs / standards
Neonatal Screening*
T-Lymphocytes*