Combined optical and acoustical detection of single microbubble dynamics

J Acoust Soc Am. 2011 Nov;130(5):3271-81. doi: 10.1121/1.3626155.

Abstract

A detailed understanding of the response of single microbubbles subjected to ultrasound is fundamental to a full understanding of the contrast-enhancing abilities of microbubbles in medical ultrasound imaging, in targeted molecular imaging with ultrasound, and in ultrasound-mediated drug delivery with microbubbles. Here, single microbubbles are isolated and their ultrasound-induced radial dynamics recorded with an ultra-high-speed camera at up to 25 million frames per second. The sound emission is recorded simultaneously with a calibrated single element transducer. It is shown that the sound emission can be predicted directly from the optically recorded radial dynamics, and vice versa, that the nanometer-scale radial dynamics can be predicted from the acoustic response recorded in the far field.

MeSH terms

  • Contrast Media*
  • Fluorocarbons*
  • Linear Models*
  • Microbubbles*
  • Nonlinear Dynamics*
  • Oscillometry
  • Particle Size
  • Phospholipids*
  • Photomicrography* / instrumentation
  • Pressure
  • Signal Processing, Computer-Assisted*
  • Surface Properties
  • Time Factors
  • Transducers
  • Ultrasonics* / instrumentation

Substances

  • BR14 contrast agent
  • Contrast Media
  • Fluorocarbons
  • Phospholipids